Case 217. Reference case 217A

       
  Double staining for EBER-1 (brown-stained nuclei by in situ hybridization) and T-cell marker, CD45RO (blue on the plasma membrane by immunostaining) in the autopsied lymph node.  
       

 

  In EB-VAHS, EBV infection occurs in NK/T cells, as shown here. The variegated clinical manifestations and hemophagocytosis are due to hypercytokinemia. This form of acute EBV infection is most commonly seen in children and young adults. Refer also to cases 34, 41 and 228.