Case 217. Reference case 217A

  Lethal EB-VAHS in a 17 y-o male, manifesting fever, pancytopenia and liver dysfunction. Enlarged abdominal lymph node was obtained at autopsy (HE).  


  In the lymph node, marked increase of leukophagocytic macrophages is observed. Normal nodal structure is lost. Nuclear atypia is absent in the lymphocytes. EB-VAHS may be lethal, in sharp contrast to infectious mononucleosis, in which self-limiting infection of EBV occurs in B-cells.