Case 91. Herpes simplex virus pneumonia (54 y-o F)

  Fatal necrotizing pneumonia associated with systemic HSV involvement in the tongue through esophagus, pancreas, rectum and urinary bladder, after immunosupressive therapy for Wegener's granulomatosis  


  HSV antigens are demonstrated both in the nuclear inclusions and in the cytoplasm, confirming diffuse involvement in the bronchial and alveolar epithelia (immunostaining).