Case 218. HIV-associated lymphadenopathy (32 y-o M)
    Biopsied cervical lymph node in an HIV carrier without any opportunistic infection    
Key words : 
human immunodeficiency virus, lymphadenopathy, folliculolysis, HTLV-1 lymphadenitis    
opportunistic infection
Follicular hyperplasia is characteristic of the stage of persistent generalized lymphadenopathy (PGL) in HIV infection. Folliculolysis is observed (HE).   Moth-eaten appearance of the enlarged germinal center (folliculolysis) is demonstrated by silver impregnation. This phenomenon is caused by HIV-induced destruction of CD21- or CD35-positive follicular dendritic cells.
Reference case 218A
HTLV-1-associated lymphadenopathy seen in an HTLV-1 carrier in Kyushu. The histologic features are nonspecific. Usually, parafollicular hyperplasia is seen, resembling features of dermatopathic lymphadenopathy (HE). Follicular hyperplasia is also observed in this case. Infiltration of atypical lymphocytes is absent.