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Case 141. Herpes simplex virus infection of vulva (28 y-o F)
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Touch smear from painful vulvar ulceration
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Key words : herpes simplex virus, vulvar ulcer
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sexually transmitted infection
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| Multiple map-like erosions focally with bulla formation are seen in the vulva (gross findings). Acute infection of HSV, type 1 accompanying severe clinical manifestation, transmitted by oral sex, is suspected. | Squamous epithelia are often multinucleated and show intranuclear inclusion bodies. Groundglass (smudgy) nuclei are characteristic (Papanicolaou). | |
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| Haloed intranuclear inclusion of Cowdry's type A is infrequently encountered. Immunostaining using anti-HSV antiserum demonstrates positive signals in both the nuclei and cytoplasm (left: Papanicolaou, right: immunostaining by re-staining method). | ||
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