Case 116. Herpes simplex virus encephalitis (28 y-o M)
Autopsied brain showing hemorrhagic encephalitis in the temporal lobe
Key words : herpes simplex virus, hemorrhagic encephalitis
In HSV encephalitis, hemorrhagic necrosis of the temporal lobe is characteristic. Histologically, intranuclear inclusions are seen mainly in neurons. Vacuolated neuropil and mild gliosis are associated (HE).   HSV-1 antigen is demonstrated in the nuclei of neurons. The inclusions bodies are immunoreactive (immunostaining).